Takao Yagi Selected Research

NADH Dehydrogenase

1/2019	Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson's Disease.
3/2013	Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
12/2009	Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.
3/2007	Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease.
11/2006	The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I.
5/2006	Possibility of transkingdom gene therapy for complex I diseases.
1/2006	Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects?

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Takao Yagi Research Topics

Disease

12	Parkinson Disease (Parkinson's Disease) 01/2019 - 09/2002
8	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 03/2005
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 09/2002
3	Neuroblastoma 03/2007 - 11/2003
2	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2015 - 07/2010
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 10/2018
1	Hypokinesia (Bradykinesia) 07/2013
1	Neuroinflammatory Diseases 07/2013
1	Weight Gain 07/2013
1	Neoplasm Metastasis (Metastasis) 03/2013
1	Breast Neoplasms (Breast Cancer) 03/2013
1	Disease Progression 03/2013
1	Neoplasms (Cancer) 03/2013
1	Malaria 09/2012
1	Tuberculosis (Tuberculoses) 09/2012
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2010
1	Tauopathies 07/2007
1	Parkinsonian Disorders (Parkinsonism) 01/2007
1	Huntington Disease (Huntington's Disease) 09/2002

Drug/Important Bio-Agent (IBA)

7	NADH DehydrogenaseIBA 01/2019 - 01/2006
7	RotenoneIBA 01/2015 - 11/2003
7	NADH dehydrogenase (quinone)IBA 08/2014 - 09/2004
3	EnzymesIBA 08/2014 - 09/2012
3	PesticidesIBA 03/2007 - 11/2003
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 12/2009
2	NAD (NADH)IBA 03/2013 - 01/2007
2	Mitochondrial DNA (mtDNA)IBA 03/2013 - 07/2010
2	Adenosine Triphosphate (ATP)IBA 07/2007 - 11/2003
2	alpha-SynucleinIBA 05/2006 - 11/2003
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2018
1	8-Hydroxy-2'-DeoxyguanosineIBA 07/2013
1	DNA (Deoxyribonucleic Acid)IBA 07/2013
1	IronIBA 07/2013
1	Biomarkers (Surrogate Marker)IBA 07/2013
1	Nicotinamide PhosphoribosyltransferaseIBA 03/2013
1	Mechanistic Target of Rapamycin Complex 1IBA 03/2013
1	Carisoprodol (Soma)FDA LinkGeneric 07/2007
1	AcetogeninsIBA 07/2007
1	annonacinIBA 07/2007
1	fenazaquinIBA 03/2007
1	fenpyroximateIBA 03/2007
1	pyridabenIBA 03/2007
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2007
1	Oxidoreductases (Dehydrogenase)IBA 01/2007
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2006
1	UbiquitinIBA 05/2006
1	Proteasome Endopeptidase Complex (Proteasome)IBA 05/2006
1	Amino Acids FDA Link 03/2005
1	AntioxidantsIBA 11/2003
1	Protons (Proton)IBA 09/2002
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 09/2002

Therapy/Procedure

3	Therapeutics 03/2013 - 11/2003
1	Microspheres (Microsphere) 07/2013